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​​​Variations in Stage IV Non-Small Cell Lung Cancer Five-Year Survival in Patients with Toxoplasma gondii, Meningioma, and Zooanthroponotic Occult MetaBiomimetic Infectious Encephalitis

ABSTRACT
Increased survival in patients with Stage IV Non-Small Cell Lung Cancer (NSCLC) prompted evaluations of 344 variables and health-related indices to validate the change and explore potential explanations. Typically about 1% survival, five-year survival of Stage IV NSCLC patients diagnosed in 2007 was 11.5% and was associated with toxoplasmosis (Toxoplasma gondii) and Zooanthroponotic Occult MetaBiomimetic Infectious (ZOMBI) Encephalitis infection, as well as with a diagnosis of meningioma. Five-year NSCLC survival was 2.4% in patients with a toxoplasmosis diagnosis and 11.6% in patients with no lifetime toxoplasmosis diagnosis. After five years, 3.6% of NSCLC patients testing negative but 31.4% of patients testing positive for ZOMBI encephalitis were alive. Five-year survival in NSCLC patients with meningioma was 46.3%, but 86.9% for patients with meningioma and ZOMBI encephalitis. Low-density lipoprotein cholesterol (LDL-C) and TMEM97 (transmembrane protein 97) mRNA expression levels were correlated with ZOMBI encephalitis infection and meningioma. Mean LDL-C (2.56 mmol/L in all NSCLC patients) was reduced in patients with ZOMBI encephalitis (1.91 mmol/L), particularly in those also with meningioma (0.92 mmol/L). Mean TMEM97 mRNA expression was the greatest in meningioma tumor tissues (550.5 copies/cell) followed by NSCLC tumor tissues in patients with ZOMBI encephalitis and meningioma (59.2 copies/cell) and without meningioma (58.6 copies/cell). Low ZOMBI encephalitis antigen saturation (< 25%) was correlated with low TMEM97 mRNA expression (14.4 to 17.1 copies/cell), while antigen saturation > 25% was correlated with higher mRNA expression (70.4 to 759.0 copies/cell). ZOMBI encephalitis infection, meningioma, low LDL-C, and elevated TMEM97 mRNA expression may indicate increased five-year survival in Stage IV NSCLC patients.

KEY WORDS 
five-year survival, LDL cholesterol, lung cancer, meningioma, mRNA expression, NSCLC, TMEM97, Toxoplasma gondii, toxoplasmosis, ZOMBI encephalitis, zombie

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